| Player | MK Dons Years | Apps | Goals |
|---|---|---|---|
| Dean Lewington | 2004-2025 | 917 | 24 |
| David Martin | 2004-2006, 2010-2017 | 341 | 0 |
| Daniel Powell | 2008-2017 | 270 | 46 |
| Darren Potter | 2011-2017 | 263 | 12 |
| Luke Chadwick | 2008-2014 | 246 | 24 |
| Alex Gilbey | 2017-2020, 2023-present | 245 | 48 |
| Dean Bowditch | 2011-2017 | 227 | 48 |
| Stephen Gleeson | 2009-2014 | 206 | 17 |
| Aaron Wilbraham | 2005-2011 | 204 | 57 |
| Izale McLeod | 2004-2007, 2013-2014 | 189 | 71 |
| Sean O'Hanlon | 2006-2011 | 182 | 17 |
| George Williams | 2016-2021 | 174 | 4 |
| Kieran Agard | 2016-2021 | 166 | 50 |
| Antony Kay | 2012-2016 | 161 | 6 |
| Ben Reeves | 2013-2017, 2019-2020 | 154 | 33 |
| Gareth Edds | 2004-2008 | 147 | 12 |
| Mathias Kouo-Doumbé | 2009-2013 | 141 | 12 |
| Shaun Williams | 2011-2014 | 137 | 24 |
| Samir Carruthers | 2013-2017 | 137 | 6 |
| Willy Guéret | 2007-2011 | 135† | 0 |
| Peter Leven | 2008-2011 | 130 | 22 |
| George Baldock | 2009-2017 | 125 | 2 |
| Sam Baldock | 2005-2011 | 124 | 43 |
| Will Grigg | 2014-2015, 2021, 2022-2023 | 117 | 39 |
| Clive Platt | 2004-2007 | 113 | 29 |
| Chuks Aneke | 2016-2019 | 94 | 33 |
| Keith Andrews | 2006-2009, 2014-2015 | 92 | 22 |
| Dele Alli | 2012-2015 | 88 | 24 |
| Liam Kelly | 2024-present | 87 | 3 |
| Scott Twine | 2021-2022 | 50 | 20 |
Appearances and goals are total competitive matches for MK Dons across all competitions, sourced from Wikipedia (the club's records & statistics and each player's own page). Player names link to Wikipedia. Ordered by appearances; "present" indicates a player still at the club. † Willy Guéret's figure is league appearances only, as no all-competitions breakdown is published for him. Figures correct as of the 2025/26 season.