Please Note – The Dons score will always be shown first.
| GAME | H/A | DATE | OPPOSITION | W/D/L | SCORE | LG POS |
| 1 | A | 07/08 | BOLTON WANDERERS | D | 3-3 | 8th |
| 2 | H | 14/08 | SUNDERLAND | L | 1-2 | 15th |
| 3 | H | 17/08 | CHARLTON ATHLETIC | W | 2-1 | 12th |
| 4 | A | 21/08 | IPSWICH TOWN | D | 2-2 | 13th |
| 5 | H | 28/08 | ACCRINGTON STANLEY | W | 2-0 | 11th |
| 6 | A | 04/09 | CHELTENHAM TOWN | D | 1-1 | 10th |
| 7 | H | 11/09 | PORTSMOUTH | W | 1-0 | 5th |
| 8 | A | 18/09 | GILLINGHAM | W | 4-1 | 3rd |
| 9 | H | 25/09 | WYCOMBE WANDERERS | W | 1-0 | 3rd |
| 10 | H | 28/09 | FLEETWOOD TOWN | D | 3-3 | 3rd |
| 11 | A | 02/10 | DONCASTER ROVERS | L | 1-2 | 6th |
| 12 | A | 16/10 | SHREWSBURY TOWN | L | 0-1 | 6th |
| 13 | A | 19/10 | WIGAN ATHLETIC | W | 2-1 | 6th |
| 14 | H | 23/10 | ROTHERHAM UNITED | L | 0-3 | 7th |
| 15 | A | 30/10 | CREWE ALEXANDRA | W | 4-1 | 7th |
| 16 | H | 13/11 | CAMBRIDGE UNITED | W | 4-1 | 5th |
| 17 | H | 20/11 | BURTON ALBION | W | 1-0 | 5th |
| 18 | A | 23/11 | SHEFFIELD WEDNESDAY | L | 1-2 | 8th |
| 19 | A | 27/11 | MORECAMBE | W | 4-0 | 6th |
| 20 | H | 8/12 | PLYMOUTH ARGYLE | D | 1-1 | 7th |
| 21 | H | 11/12 | OXFORD UNITED | L | 1-2 | 9th |
| 22 | A | 26/12 | LINCOLN CITY | W | 3-2 | 7th |
| 23 | H | 01/01 | GILLINGHAM | D | 0-0 | 7th |
| 24 | A | 08/01 | ACCRINGTON STANLEY | D | 1-1 | 7th |
| 25 | H | 11/01 | AFC WIMBLEDON | W | 1-0 | 5th |
| 26 | A | 15/01 | PORTSMOUTH | W | 2-1 | 5th |
| 27 | H | 22/01 | DONCASTER ROVERS | L | 0-1 | 5th |
| 28 | A | 25/01 | BURTON ALBION | W | 1-0 | 5th |
| 29 | A | 29/01 | WYCOMBE WANDERERS | W | 1-0 | 4th |
| 30 | H | 05/02 | LINCOLN CITY | W | 2-1 | 3rd |
| 31 | A | 08/02 | FLEETWOOD TOWN | D | 1-1 | 3rd |
| 32 | H | 12/02 | IPSWICH TOWN | D | 0-0 | 3rd |
| 33 | A | 19/02 | SUNDERLAND | W | 2-1 | 3rd |
| 34 | A | 22/02 | CHARLTON ATHLETIC | W | 2-0 | 3rd |
| 35 | H | 26/02 | BOLTON WANDERERS | W | 2-0 | 3rd |
| 36 | A | 05/03 | ROTHERHAM UNITED | W | 2-1 | 3rd |
| 37 | H | 09/03 | CHELTENHAM TOWN | W | 3-1 | 3rd |
| 38 | H | 12/03 | WIGAN ATHLETIC | D | 1-1 | 3rd |
| 39 | A | 19/03 | CAMBRIDGE UNITED | W | 1-0 | 3rd |
| 40 | H | 02/04 | SHREWSBURY TOWN | W | 2-0 | 3rd |
| 41 | H | 05/04 | CREWE ALEXANDRA | W | 2-1 | 2nd |
| 42 | A | 09/04 | AFC WIMBLEDON | D | 1-1 | 2nd |
| 43 | H | 16/04 | SHEFFIELD WEDNESDAY | L | 2-3 | 3rd |
| 44 | A | 19/04 | OXFORD UNITED | L | 0-1 | 3rd |
| 45 | H | 23/04 | MORECAMBE | W | 2-0 | 3rd |
| 46 | A | 30/04 | PLYMOUTH ARGYLE | W | 5-0 | 3rd |
SEASON 2021/22 LEAGUE 1 PLAYOFFS
| A | 05/05 | WYCOMBE WANDERERS | L | 0-2 |
| H | 08/05 | WYCOMBE WANDERERS | W | 1-0 |